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Chỉ định và Liều dùng
Intravenous
Scorpion envenomation Adult: Initially, 3 vials via IV infusion over 10 minutes, additional vials may be administered at 1-vial increments every 30-60 minutes as necessary.
Child: Same as adult dose. |
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Hướng dẫn pha thuốc
Reconstitute vial with 5 mL of NaCl 0.9%. Further dilute dose with NaCl 0.9% to a total volume of 50 mL.
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Thận trọng
Patients with known allergies to horse protein; previous treatment with Centruroides immune F(ab')2 or other equine-derived antivenom/antitoxin. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Anaphylaxis, anaphylactoid reactions, delayed serum sickness; disease transmission (obtained from equine plasma).
Cardiac disorders: Chest tightness, palpitation. Eye disorders: Ocular oedema. Gastrointestinal disorders: Nausea, vomiting, diarrhoea. General disorders and administration site conditions: Fatigue, lethargy. Nervous system disorders: Headache. Musculoskeletal and connective tissue disorders: Myalgia. Respiratory, thoracic and mediastinal disorders: Rhinorrhoea, cough, aspiration, hypoxia, respiratory distress. Skin and subcutaneous tissue disorders: Rash, pruritus. |
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Chỉ số theo dõi
Monitor for signs and symptoms of envenomation (e.g. opsoclonus, involuntary muscle movement, slurred speech, paraesthesia, respiratory disress, vomiting, frothy sputum, salivation), serum sickness (e.g. fever, joint pain, muscle pain, rash), and acute antivenom hypersensitivity reactions (e.g. fever, myalgia, arthralgia, rash).
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Tác dụng
Description:
Mechanism of Action: Scorpion venom antisera is a polyvalent antivenom that contains venom-specific F(ab') fragments of IgG which bind and neutralise venom toxins. It facilitates the removal of the toxin from the target tissue and eliminates it from the body. Onset: Time to resolution of symptoms: 1.91 ± 1.4 hours. Pharmacokinetics: Excretion: Elimination half-life: 159 ± 57 hours. |
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Bảo quản
Store at 25°C. Do not freeze.
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Phân loại MIMS
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Tài liệu tham khảo
Anascorp Injection, Powder, Lyophilized, for Solution (Rare Disease Therapeutics, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 31/08/2023. Anon. Centruroides Immune F(ab’)2 (Equine). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 31/08/2023. Anon. Centruroides Immune F(ab′)2. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 31/08/2023. Scorpion Antivenin, Antivenin Centruroides sculpturatus Equine. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 31/08/2023.
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